Severity

Osteoporosis is the main cause of all fractures in women post-menopause and older men. These fractures are a great public health concern:

• 21-30% of people die within 12 months after hip fracture

• Among survivors, many have chronic pain, loss of mobility (40% who experience any osteoporotic fracture are unable to walk independently at 1 year; 60% require assistance with at least 1 essential activity of daily life) and must enter long-term care facilities

• 10% mortality rate after rib fracture; 8x increase in mortality rate after vertebral fracture

• $400k yearly spent per U.S. patient for hip fracture care – not including long-term care

• $141k-146k care + $46k work absence, disability per vertebral fracture

• The annual cost of osteoporotic fractures for the Medicare population alone was $57 billion in 2018 and forecast to rise to over $95 billion by 2040 with the aging population